Ziatozone is a topical massage cream containing ozonated oil, menthol, eucalyptus, camphor, amino acids (arginine, leucine, valine, glutamic acid), and Harpagophytum (Devil’s Claw) root extract. It relieves pain through multiple mechanisms: • Anti inflammatory action: Ozonated oil and Devil’s Claw inhibit inflammatory enzymes (like COX), reducing local inflammation. Ozone also modulates oxidative stress and promotes antioxidant defense. • Analgesic effect: Menthol and camphor activate TRP channels to deliver a cooling/warming counter irritant effect that masks pain. • Circulation & muscle recovery: Arginine supports nitric oxide production, improving microcirculation; branched-chain amino acids help reduce delayed-onset muscle soreness.
• Osteoarthritis and joint pain (knee, hip, shoulder) • Muscle strains, ligament sprains, and sports injuries • Post-exercise muscle soreness (DOMS) • Tension and inflammatory soft-tissue pain
Apply a thin layer of Ziatozone on clean, dry skin over the affected area. Massage in circular motions until fully absorbed. Use 2–3 times daily or after intense activity for optimal results.
Many users notice a cooling/warming soothing sensation immediately. Significant pain reduction and inflammation relief often appear within 3–5 days of regular use. Long term benefits may emerge within 1–2 weeks.
It’s generally safe when used topically. Mild reactions like skin redness or irritation may occur from menthol or camphor. Ozone oil and Devil’s Claw have been well-tolerated in clinical settings. • Allergies: Rare skin reactions possible. • Devil’s Claw oral use: May cause stomach upset or interact with medications, but topical use minimizes this risk.
No, avoid applying Ziatozone on open wounds, cuts, or mucous membranes (eyes, mouth). Use only on healthy, intact skin.
Elderly individuals can use it safely. However, pregnant or breastfeeding women, and children under 5, should consult a physician before use due to limited data.
It’s best not to mix Ziatozone with other NSAID gels or menthol-containing products simultaneously, as this may lead to skin irritation or compounded effects.
Depending on usage frequency, a standard tube (typically 50–100 mL) lasts 2–4 weeks. Exact duration varies by application thickness and treated area.
Topical use causes minimal systemic absorption, so drug interactions are unlikely. However, patients using anticoagulants, diabetes medication, or anti hypertensives should consult their physician, especially if using Harpagophytum extract.
Recommended for adults and seniors. Use in children under 5 is not advised. Older adults with comorbid conditions should consult a healthcare provider.
Yes. A randomized, placebo-controlled trial demonstrated that topical ozonated oil significantly relieved pain in severe knee osteoarthritis patients (PubMed). Devil’s Claw extract has shown similar results to NSAIDs in arthritis pain relief (Versus Arthritis).
Up to 2–3 times per day. Do not exceed 4 applications in 24 hours or use it under occlusive dressings without medical advice.
Absolutely. The ozonated oil supports circulation and recovery, while amino acids help reduce post-exercise muscle soreness (DOMS).
Store in a cool (<30 °C), dry place away from direct sunlight. Keep the cap tightly sealed to maintain stability.
